/* style.css */
*,
*::before,
*::after {
  box-sizing: border-box;
}

html {
  font-size: 16px;
}

body {
  margin: 0;
  font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "Segoe UI", "YuGothic", "Yu Gothic", "Hiragino Kaku Gothic ProN", "Meiryo", sans-serif;
  line-height: 1.7;
  color: #24323f;
  background-color: #f5f7fa;
}

/* Layout helpers */
.container {
  width: 100%;
  max-width: 960px;
  margin: 0 auto;
  padding: 0 1rem;
}

/* Header */
.site-header {
  background: linear-gradient(135deg, #1c6dd0, #46a3ff);
  color: #ffffff;
  padding: 1.5rem 0;
  box-shadow: 0 2px 6px rgba(0, 0, 0, 0.12);
}

.site-title {
  margin: 0;
  font-size: 1.4rem;
  font-weight: 600;
}

.site-subtitle {
  margin: 0.3rem 0 0;
  font-size: 0.95rem;
  opacity: 0.9;
}

/* Footer */
.site-footer {
  margin-top: 2rem;
  padding: 1.5rem 0;
  text-align: center;
  font-size: 0.85rem;
  color: #74808b;
}

/* Breadcrumb */
.breadcrumb {
  margin: 1rem 0 1.5rem;
  font-size: 0.9rem;
  color: #788898;
}

.breadcrumb a {
  color: #1c6dd0;
  text-decoration: none;
}

.breadcrumb a:hover {
  text-decoration: underline;
}

/* Disease section */
.disease-section {
  background-color: #ffffff;
  border-radius: 0.75rem;
  padding: 1.5rem 1.5rem 2rem;
  box-shadow: 0 4px 12px rgba(15, 35, 52, 0.06);
  margin-bottom: 2rem;
}

.disease-header {
  border-bottom: 1px solid #e1e7ef;
  padding-bottom: 1rem;
  margin-bottom: 1rem;
}

.disease-name {
  margin: 0 0 0.4rem;
  font-size: 1.4rem;
  color: #16324f;
}

.disease-lead {
  margin: 0;
  font-size: 0.95rem;
  color: #4f5b66;
}

/* Info blocks */
.info-block {
  margin-top: 1.2rem;
  padding: 1rem 0.5rem 0.5rem;
  border-top: 1px dashed #dde4ee;
}

.section-title {
  margin: 0 0 0.4rem;
  font-size: 1.05rem;
  font-weight: 600;
  color: #1c6dd0;
}

.section-body {
  margin: 0.2rem 0 0.6rem;
  font-size: 0.95rem;
  color: #3a4652;
}

/* Lists */
.section-list {
  margin: 0.3rem 0 0.7rem 1.1rem;
  padding: 0;
  font-size: 0.95rem;
  color: #3a4652;
}

.section-list li {
  margin-bottom: 0.3rem;
}

/* Strong text in lists */
.section-list strong {
  font-weight: 600;
  color: #16324f;
}

/* Responsive */
@media (max-width: 600px) {
  .site-header {
    padding: 1.2rem 0;
  }

  .disease-section {
    padding: 1.2rem 1.1rem 1.5rem;
  }

  .disease-name {
    font-size: 1.25rem;
  }

  .section-title {
    font-size: 1rem;
  }
}